Getting down to basics

Acute chest syndrome: Getting down to the basics

Acute chest syndrome (ACS) is one of the most common causes of death and hospitalization among patients with a sickle hemoglobinopathy. The clinical presentation is characterized by the appearance of a new infiltrate on a chest radiograph, with 1 or more new symptoms, including fever, cough, chest pain, and dyspnea. Additional findings include leukocytosis, hypoxemia, and auscultatory signs of ...

Getting Back to Basics

Advances in understanding basic developmental and physiological processes often have direct relevance to human disease. They provide insights into pathogenic mechanisms and reveal new pathways that can be exploited in diagnosis and the development of therapeutics.

Getting Back to the Basics of Translational Research

How do viruses cause cancer? As a naïve graduate student in the years before kits and personal computers, I found myself fascinated by viral “immortalization,” the process by which a virus induces a cell to live forever. The immortalizing virus of interest was named Epstein–Barr Virus (EBV) after its co-discoverers and was isolated from tumors commonly found in African children. EBV was also kn...

Mechanotransduction: Getting Morphogenesis Down Pat

Embryonic morphogenesis requires the coordination of forces across multiple tissues and their associated extracellular matrices. A new study reports a mechanical feedback loop in the Caenorhabditis elegans embryo between muscle and epidermis that may provide a model for understanding how tissues coordinate morphogenetic events in the embryo.

EMR Implementation: Benefits of Getting Staff Trained on the Basics